Síndrome das Pernas Inquietas
Revisão e Atualização
DOI:
https://doi.org/10.4181/RNC.2009.17.263Palavras-chave:
Síndrome das Pernas Inquietas, Medicina Tradicional Chinesa, Distúrbios do SonoResumo
A Síndrome das Pernas Inquietas (SPI) é um distúrbio sensório-motor que causa grande desconforto em seus portadores, e ainda é pouco conhecido pela população e por profissionais da área médica. Pela falta de conhecimentos, muitos pacientes recebem diagnóstico errado e tratamento inadequado. Recentemente, os componentes genéticos da SPI têm sido mais estudados e compreendidos, o que pode melhorar o entendimento da fisiopatologia desta doença. O objetivo deste estudo é apresentar uma revisão e atualização sobre os conhecimentos a respeito da SPI, incluindo métodos diagnósticos mais empregados e as opões de tratamento, buscando sempre a melhor evidência científica para cada situação.
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Zucconi M, Ferini-Strambi L. Epidemiology and clinical findings of restless legs syndrome. Sleep Med 2004;5: 293-9.
Prado GF. Síndrome das pernas inquietas: há quanto tempo é ignorada? Rev Neurocienc 2002;10:38-43.
Ekbom KA. Restless Legs. Acta Med Scand 1945;suppl:158.
Masuko AH, Prado LBF, Prado GF. Síndrome das Pernas Inquietas. Rev Neurocienc 2004;12:18-20.
Phillips B, Young T, Finn L, Asher K, Hening WA, Purvis C. Epidemiology of restless legs syndrome in adults. Arch Intern Med 2000;160:2137–41.
Rothdach AJ, Trenkwalder C, Haberstok J, Keil U, Berger K. Prevalence and risk factors of RLS in elderly population. Neurology 2000;54:1064-8.
Walters AS, Hickey K, Maltzman J, Verrico T, Joseph D, Hening W, et al. A questionnaire study of 138 patients with restless legs syndrome: the ‘Night-Walkers’ survey. Neurology 1996;46:92-5.
Sun ER, Chen CA, Ho G, Earley CJ, Allen RP. Iron and the restless legs syndrome. Sleep 1998;21:371-7.
Allen RP, Barker PB, Wehrl F, Song HK, Earley CJ. MRI measurements of brain iron in patients with restless legs syndrome. Neurology 2001;56:263-5.
O’Keeffe ST, Gavin K, Lavan JN. Iron status and Restless Legs Syndrome in the elderly. Age Aging 1994;23:200-3.
Gemignani F, Brindani F, Negrotti A, Vitetta F, Alfieri S, Marbini A. Restless legs syndrome and polyneuropathy. Mov Disord 2006;21:1254-7.
Rutkove SB, Matheson JK, Logigian EL. Restless legs syndrome in patients with polyneuropathy. Mus Nerv 1996;19:670-2.
Manconi M, Govoni V, De Vito A, Economou NT, Cesnik E, Casetta I, et al. Restless legs syndrome and pregnancy. Neurology 2004;63:1065-9.
Pien GW, Schwab RJ. Sleep disorders during pregnancy. Sleep 2004;27:1405-17.
Wetter TC, Stiasny K, Kohnen R, Oertel WH, Trenkwalder C. Polysomnographic sleep measures in patients with uremic and idiopathic restless legs syndrome. Mov Disord 1998;13:820-4.
Winkelman JW, Chertow GM, Lazarus JM. Restless legs syndrome in end-stage renal disease. Am J Kidney Dis 1996;28:372-8.
Ondo W, Tan EK, Mansoor J. Rheumatologic serologies in secondary restless legs syndrome. Mov Disord 2000; 15:321-3.
Reynolds G, Blake DR, Pall HS, Williams A. Restless leg syndrome and rheumatoid arthritis. Br Med J (Clin Res Ed) 1986;292:659-60.
Yunus MB, Aldag JC. Restless legs syndrome and leg cramps in fibromyalgia syndrome: a controlled study. BMJ 1996;312:1339.
Rye DB. Parkinson’s disease and RLS: the dopaminergic bridge. Sleep Med 2004;5:317-28.
Ondo WG, Vuong KD, Jankovic J. Exploring the relationship between Parkinson disease and restless legs syndrome. Arch Neurol 2002;59:421-4.
Prado GF, Allen RP, Trevisani VM, Toscano VG, Earley CJ. Sleep disruption in systemic sclerosis (scleroderma) patients: clinical and polysomnographic findings. Sleep Med 2002;3:341-5.
Garvey MJ, Tollefson GD. Occurrence of myoclonus in patients treated with cyclic antidepressants. Arch Gen Psychiatr 1987;44:269-72.
Bakshi R. Fluoxetine and restless legs syndrome. J Neurol Sci 1996;142:151-2.
Terao T, Terao M, Yoshimura R, Abe K. Restless legs syndrome induced by lithium. Biol Psychiatr 1991;30:1167-70.
Ward NG. Akathisia associated with droperidol during epidural anesthesia. Anesthesiol 1989;71:786-7.
Lutz EG. Restless legs, anxiety and caffeinism. J Clin Psychiatr 1978;39:693-8.
Sforza E, Mathis J, Bassetti CL. Restless legs syndrome: pathophysiology and clinical aspects. Schweiz Arch Neurol Psychiatr 2003;7:349-57.
Walters AS. Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group. Mov Disord 1995;10:634-42.
Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless Legs Syndrome Diagnosis and Epidemiology workshop at the National Institutes of Health; International Restless Legs Syndrome Study Group. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 2003;4:101-19.
Atkinson MJ, Allen RP, DuChane J, Murray C, Kushida C, Roth T. RLS Quality of Life Consortium. Validation of the Restless Legs Syndrome Quality of Life Instrument (RLS-QLI): findings of a consortium of national experts and the RLS Foundation. Qual Life Res 2004;13:679-93.
Abetz L, Arbuckle R, Allen RP, Mavraki E, Kirsch J. The reliability, validity and responsiveness of the Restless Legs Syndrome Quality of Life questionnaire (RLSQoL) in a trial population. Health Qual Life Outcomes 2005;3:79.
Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, et al. International Restless Legs Syndrome Study Group. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 2003;4:121-32.
Masuko AH, Carvalho LBC, Machado MAC, Morais JF, Prado LBF, Prado GF. Translation and validation into the Brazilian Portuguese of the Restless Legs Syndrome Rating Scale of the International Restless Legs Syndrome Study Group. Arq Neuropsiquiatr 2008;66:832-6.
Kohen R, Oertel WH, Stiasny-Kosler, Benes H, Trenkwalder C. Severity rating of RLS: review of ten years experienced with RLS-6 scales in clinical trials [abstract]. Sleep 2003;26(Abs suppl):A342.
Hening WA, Allen RP, Thanner S, Washburn T, Heckler D, Walters AS, et al. The Johns Hopkins telephone diagnostic interview for the restless legs syndrome: preliminary investigation for validation in a multi-center patient and control population. Sleep Med 2003;4:137-41.
Hening WA, Allen RP, Earley CJ, Bell G. Validation of a single question that can screen for the restless legs syndrome (RLS). Sleep 2006;29(Abs suppl):0862.
Montplaisir J, Boucher S, Poirier G, Lavigne G, Lapierre O, Lesperance P. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord 1997;12:61-5.
Montplaisir J, Michaud M, Denesle R, Gosselin A. Periodic leg movements are not more prevalent in insomnia or hypersomnia but are specifically associated with sleep disorders involving a dopaminergic impairment. Sleep Med 2000;1:163-7.
Zucconi M, Ferri R, Allen R, Baier PC, Bruni O, Chokroverty S, et al. International Restless Legs Syndrome Study Group (IRLSSG). The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Group (IRLSSG). Sleep Med 2006;7:175-83.
Ferri R, Zucconi M, Manconi M, Plazzi G, Bruni O, FeriniStrambi L. New approaches to the study of periodic leg movements during sleep in restless legs syndrome. Sleep 2006;29:759-69.
Montplaisir J, Boucher S, Nicolas A, Lesperance P, Gosselin A, Rompre P, et al. Immobilization tests and periodic leg movements in sleep for the diagnosis of restless leg syndrome. Mov Disord 1998;13:324-9.
Montplaisir J, Lorrain D, Godbout R. Restless legs syndrome and periodic leg movements in sleep: the primary role of dopaminergic mechanism. Eur Neurol 1991;31:41-3.
Ruottinen HM, Partinen M, Hublin C, Bergman J, Haaparanta M, Solin O, et al. An FDOPA PET study in patients with periodic limb movement disorder and restless legs syndrome. Neurology 2000;54:502–4.
Cervenka S, Palhagen SE, Comley RA, Panagiotidis G, Cselenyi Z, Matthews JC, et al. Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding. Brain 2006;129:2017-28.
Michaud M, Soucy JP, Chabli A, Lavigne G, Montplaisir J. SPECT imaging of striatal pre- and postsynaptic dopaminergic status in restless legs syndrome with periodic leg movements in sleep. J Neurol 2002;249:164–70.
Turjanski N, Lees AJ, Brooks DJ. Striatal dopaminergic function in restless legs syndrome. Neurology 1999;52: 932–7.
Sloand JA, Shelly MA, Feigin A, Bernstein P, Monk RD. A double-blind, placebo-controlled trial of intravenous iron dextran therapy in patients with ESRD and restless legs syndrome. Am J Kidney Dis 2004;43:663-70.
Earley CJ, Heckler D, Allen RP. Repeated IV doses of iron provides effective supplemental treatment of restless legs syndrome. Sleep Med 2005;6:301-5.
Sun ER, Chen CA, Ho G, Earley CJ, Allen RP. Iron and the restless legs syndrome. Sleep 1998;21:371-7. 57.Winkelmann J, Ferini-Strambi L. Genetics of restless legs syndrome. Sleep Med Rev 2006;10:179-83.
Allen RP, Earley CJ. Restless legs syndrome. A review of clinical and pathophysiologic features. J Clin Neurophysiol 2001;18:128–47.
Allen RP, Barker PB, Wehrl F, Song HK, Early CJ. MRI measurement of brain iron in patients with restless legs syndrome. Neurology 2001;56:263–5.
Ondo WG, He Y, Rajasekaran S, Le WD. Clinical correlates of 6-Hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome? Mov Disord 2000;15:154–8.
Schols L, Haan J, Riess O, Amoiridis G, Przuntek H. Sleep disturbances in patients with hereditary ataxias. Neurology 1998;51:1603–7.
Bara-Jimenez W, Aksu M, Graham B, Sato S, Hallett M. Periodic limb movements in sleep: state-dependent excitability of the spinal flexor reflex. Neurology 2000;54:1609-16.
Schober T, Wenzel K, Feichtinger M, Schwingenschuh P, Strebel A, Krausz G, et al. Restless legs syndrome: changes of induced electroencephalographic beta oscillations—an ERD/ERS study. Sleep 2004;27:147-50.
Winkelmann J, Ferini-Strambi L. Genetics of restless legs syndrome. Sleep Med Rev 2006;10:179-83.
Chen S, Ondo WG, Rao S, Li L, Chen Q, Wang Q. Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p. Am J Hum Genet2004;74:876-85.
Desautels A, Turecki G, Montplaisir J, Xiong L, Walters AS, Ehrenberg BL, et al. Restless legs syndrome: confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity. Arch Neurol 2005;62:591-6.
Bonati MT, Ferini-Strambi L, Aridon P, Oldani A, Zucconi M, Casari G. Autosomal dominant restless legs syndrome maps on chromosome 14q. Brain 2003;126:1485- 92.
Pichler I, Marroni F, Beu Volpato C, Gusella JF, Klein C, Casari G, et al. Linkage analysis identifies a novel locus for restless legs syndrome on chromosome 2q in a South tyrolean population isolate. Am J Hum Genet 2006;79: 716-23.
Levchenko A, Provost S, Montplaisir JY, Xiong L, St-Onge J, Thibodeau P, et al. A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13. Neurology 2006;67:900-1.
Winkelmann J, Schormair B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, et al. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet 2007;39:1000-6.
Conti CF, de Oliveira MM, Valbuza JS, Prado LB, de Carvalho LB, do Prado GF. Anticonvulsants to treat idiopathic restless legs syndrome: systematic review. Arq Neuropsiquiatr 2008;66:431-5..
Conti CF, de Oliveira MM, Andriolo RB, Saconato H, Atallah AN, Valbuza JS, et al. Levodopa for idiopathic restless legs syndrome: evidence-based review. Mov Disord 2007;22:1943-51.
Saletu M, Anderer P, Högl B, Saletu-Zyhlarz G, Kunz A, Poewe W, et al. Acute double-blind, placebo-controlled sleep laboratory and clinical follow up studies with a combination treatment of rr-L-dopa and sr-L-dopa in restless legs syndrome. J Neural Transm 2003;110:611-26.
Trenkwalder C, Stiasny K, Pollmächer T, Wetter T, Schwarz J, Kohnen R, et al. L-dopa therapy of uremic and idiopathic restless legs syndrome: a double-blind, crossover trial. Sleep 1995;18:681-8.
Bliwise DL, Freeman A, Ingram CD, Rye DB, Chakravorty S, Watts RL. Randomized, double-blind, placebo-controlled, short-term trial of ropinirole in restless legs syndrome. Sleep Med 2005;6:141-7.
Adler CH, Hauser RA, Sethi K, Caviness JN, Marlor R, Anderson WM, et al. Ropinirole for restless legs syndrome a placebocontrolled crossover trial. Neurology 2004;62:1405-7.
Trenkwalder C, Paulus W, Walters AS. The Restless Legs syndrome Review. The lancet Neurol 2005;4:465-75.
Earley CJ, Allen RP. Pergolide and carbidopa/levodopa treatment of restless legs syndrome and periodic leg movements in sleep in a consecutive series of patients. Sleep 1996;19:801-10.
Allen RP, Earley CJ. Augmentation of the restless legs syndrome with carbidopa levodopa. Sleep 1996;14:629-50.
Silva Filho RC, Ferreira VR, Ruotolo F, Carvalho LB, Prado LF, Prado GF. Acupuncture in the treatment of restless legs syndrome, a promissory therapy. Sleep 2006;26(Abs suppl):A843.
Wang W, Fan H. Fifty cases of child restless syndrome treated with the integrated method of Chinese herbal drugs and auricular-plaster therapy. J Tradit Chin Med 2005;25:276-7
Wu YH, Sun CL, Wu D, Huang YY, Chi CM. Observation on therapeutic effect of acupuncture on restless legs syndrome. Zhongguo Zhen Jiu 2008;28:27-9.
Cui Y, Wang Y, Liu Z. Acupuncture for restless legs syndrome. Cochrane Database Syst Rev 2008 8:CD006457.
Aukerman MM, Aukerman D, Bayard M, Tudiver F, Thorp L, Bailey B. Exercise and restless legs syndrome: a randomized controlled trial. J Am Board Fam Med 2006;19:487-93.
Montagna P, Sassoli de Bianchi L, Zucconi M, Cirignotta F, Lugaresi E. Clonazepam and vibration in restless legs syndrome. Acta Neurol Scand 1984;69:428-30.
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Publicado: 2009-09-30
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