O papel da vitamina D na regulação do ciclo sono-vigília
DOI:
https://doi.org/10.34024/rnc.2023.v31.15314Palavras-chave:
Vitamina D, Sono, Neurofisiologia, Ritmo CircadianoResumo
Introdução. A vitamina D exerce diversas funções no organismo, incluindo a regulação do ciclo sono-vigília, visto que sua deficiência está associada a distúrbios do sono. Entretanto, os mecanismos biológicos para esse controle não são totalmente conhecidos. Objetivo. Analisar os principais mecanismos de atuação da vitamina D na regulação do ciclo sono-vigília. Método. Revisão integrativa da literatura, realizada com pesquisa bibliográfica nas bases de dados Scielo, Pubmed e Biblioteca Virtual em Saúde, com os seguintes descritores retirados das plataformas DeCS e MeSH: “vitamin D”, “sleep”, “vitamina D” e “sono”. Foram incluídos trabalhos publicados nos últimos 5 anos e com textos completos. Resultados. Após revisão pormenorizada dos 476 resultados obtidos, foram selecionados 23 artigos para compor esta revisão. As principais hipóteses encontradas para explicar a regulação da vitamina D sobre o ciclo sono-vigília incluíram sua participação na síntese de melatonina e de neurotransmissores essenciais para as vias neurais envolvidas no ciclo sono-vigília, assim como no desenvolvimento dos neurônios que integram essas vias. Ademais, postula-se seu papel na modulação imunológica e na desintoxicação do sistema nervoso central. Conclusão. Evidencia-se a importância de compreender os possíveis mecanismos de regulação do ciclo sono-vigília pela vitamina D, principalmente pela possibilidade de explorar a fisiopatologia dos distúrbios do sono. Porém, mais estudos são necessários para esclarecer outros possíveis mecanismos de regulação.
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Copyright (c) 2023 Danilo José Silva Moreira, Suzana dos Santos Vasconcelos, Vinicius Faustino Lima de Oliveira, Juliana Brito da Fonseca, Karoline Rossi, Elane de Nazaré Magno Ferreira
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Aceito: 2023-10-11
Publicado: 2023-10-30
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