Alterações Comportamentais e de Estresse Oxidativo no Sistema Nervoso Central pelo Uso de Álcool e Tabaco
DOI:
https://doi.org/10.34024/rnc.2012.v20.8256Palavras-chave:
Etanol, Cérebro, Estresse Oxidativo, Tabaco, ToxicidadeResumo
Álcool e tabaco são as drogas lícitas mais consumidas no mundo ocidental, frequentemente utilizadas em associação. Tanto o álcool quanto o tabaco influenciam individualmente sistemas neurotransmissores, interferindo no comportamento de indivíduos expostos a eles, além de afetarem mecanismos pró e antioxidantes, com risco de dano neuronal promovido por espécies reativas de oxigênio. Pouco se sabe sobre os efeitos de sua associação sobre estes mesmos parâmetros. Neste contexto, o objetivo deste estudo foi revisar os dados da literatura sobre os efeitos do álcool, cigarro ou sua associação sobre sistemas neurotransmissores, sobre comportamentos e parâmetros de estresse oxidativo no sistema nervoso central de animais. Para contemplar esse objetivo fizemos extensa revisão de literatura, limitando as buscas desde o ano de 1970 até o ano de 2010. Embora os estudos sobre os efeitos da associação entre álcool e cigarro sejam ainda escassos, eles sugerem que estas substâncias afetam a neurotransmissão, modificando comportamentos, assim como aumentam a concentração de espécies reativas de oxigênio, interferindo sobre mecanismos antioxidantes.
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Publicado: 2012-09-30