Hemosiderina, um possível biomarcador para sudep?
DOI:
https://doi.org/10.34024/rnc.2021.v29.12514Palavras-chave:
Epilepsia, SUDEP, espécies reativas de oxigênioResumo
A epilepsia é uma das doenças neurológicas de etiologia complexa que afeta em torno de 50 milhões de pessoas em todo o mundo, e é caracterizada por atividade elétrica anormal e convulsões recorrentes. As convulsões tônico-clônicas generalizadas repetitivas descontroladas (GTCS) são as principais causas de morte súbita inesperada em epilepsia (SUDEP). O estresse hipóxico induzido pela crise epiléptica resulta em disfunções neurocardiogênica, incluindo a sobrecarga de ferro a cardiomiopatia (IOC) que está relacionada à peroxidação lipídica grave causada pela produção de espécies reativas de oxigênio (ROS). A ROS induz a atividade convulsiva recorrente, favorecendo a superexpressão da glicoproteína P (P-gp) no coração. A P-gp desempenha uma função despolarizante em membranas de cardiomiócitos e os canais de potássio (Kir) controlam a excitabilidade celular quanto a repolarização do potencial de ação cardíaco. Todos esses acontecimentos resultam num possível aparecimento de bradicardia severa e arritmia fatal. Diversos estudos têm buscado evidências para diferentes possíveis biomarcadores para potencial previsão do risco de SUDEP evitando seu desfecho fatal.
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Copyright (c) 2021 Andressa Sampaio Pereira, Patrícia de Morais Ferreira Brandão, Jerónimo A Auzmend, Alberto Lazarowski
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Publicado: 2021-08-05
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