Sobre o Autismo, Neuroinflamação e Modelos Animais para o Estudo de Autismo:

Uma Revisão

Autores

  • Maria Martha Bernardi Neurocientista, Doutora, Professor adjunto da Faculdade de Pedagogia do Centro de Ciências e Humanidades, Universidade Presbiteriana Mackenzie, São Paulo, SP, Brasil, e pesquisadora do Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo- SP, Brasil.
  • Thiago Berti Kirsten Biólogo, Mestre, Doutorando do Programa de Pós-graduação em Patologia Experimental e Comparada do Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo-SP, Brasil.
  • Mácio Oliveira Trindade Bacharel em Educação, Mestrando do Programa de Educação, Arte e História da Cultura da Universidade Presbiteriana Mackenzie, Professor Assistente do Centro de Ciências e Humanidades da Universidade Presbiteriana Mackenzie, São Paulo-SP, Brasil.

DOI:

https://doi.org/10.34024/rnc.2012.v20.8304

Palavras-chave:

Autismo, Comportamento Animal, ranstornos do Desenvolvimento Infantil, Modelos Animais

Resumo

Este artigo busca mostrar a relevância de modelos animais no estudo da síndrome autista por meio de revisão da literatura. Embora eles pos­sam ser discutidos pela sua limitação, a contribuição no entendimento da síndrome e possibilidades de procedimentos que não são possíveis em humanos por razões éticas permite desvendar alguns aspectos dessa desordem. O autismo é um distúrbio psiquiátrico de desenvolvimento que se caracteriza por alterações comportamentais desde a infância, tais como prejuízo na comunicação, na interação social, além de mo­vimentos repetitivos e estereotipados e dificuldades de aprendizado. Esses sintomas podem ser severos ou moderados e/ou parciais, além de nenhuma manifestação ser exclusiva desse transtorno, o que dificulta o diagnóstico. Os achados neuroanatômico-funcionais são inespecí­ficos, assim como os estudos genéticos. Além da eventual predispo­sição genética, fatores ambientais, como a neuroinflamação, podem aumentar a incidência do autismo. A corrente de estudos atribuindo distúrbios mentais, inclusive o autismo, a alterações imunes se apóia cada vez mais em inúmeras publicações recentes, envolvendo acha­dos neuroimunes e desenvolvimento de diversos modelos animais. O presente trabalho realizou uma revisão sobre o autismo, discutindo a contribuição dos modelos animais para o estudo desta síndrome, além de discorrer sobre a participação da neuroinflamação como um fator associado à gênese desta patologia.

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2012-03-31

Como Citar

Bernardi, M. M., Kirsten, T. B., & Trindade, M. O. (2012). Sobre o Autismo, Neuroinflamação e Modelos Animais para o Estudo de Autismo:: Uma Revisão. Revista Neurociências, 20(1), 117–127. https://doi.org/10.34024/rnc.2012.v20.8304

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Artigos de Revisão
Recebido: 2019-02-18
Publicado: 2012-03-31