Microbiota Intestinal e Sistema Nervoso Central: explorando o eixo cérebro e intestino
DOI:
https://doi.org/10.34024/rnc.2022.v30.12129Palavras-chave:
microbiota, microbiota intestinal, microbioma intestinal, cognição, sistema nervoso centralResumo
Introdução. Estudos correlacionam a comunicação bidirecional entre microbiota intestinal e sistema nervoso central associado a transtorno cognitivos e neurodegenarativos e sintomas intestinais. Objetivo. Identificar a relação entre microbiota intestinal e o cérebro. Método. Foi conduzida uma busca sistemática nas bases de dados Pubmed e Bireme. Resultados. A comunicação entre o cérebro e a microbiota intestinal se dá pela via colinérgica aferente e eferente; pelo sistema HPA onde o estímulo ocorre por via aferente, e por inibição de histonas pela via eferente. A microbiota intestinal e sua composição estão conectadas ao desenvolvimento de patologias do sistema nervoso central e sua prevenção. Estas patologias têm relação com o eixo cérebro-intestino e a liberação de metabólitos que afetam diretamente a permeabilidade do intestino. Conclusão. Alterações na mucosa interferem na liberação de hormônios e de neurotransmissores gastrointestinais, assim estudos observam melhora cognitiva a partir da suplementação de pré e Probióticos.
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Copyright (c) 2022 Júlia Carolina Lopes Silva, Sarah Évelin Dias Campos Campos, Matheus Luis Cobel de Santana, André dos Santos Costa, Jakeline Olindina Francelino
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Aceito: 2022-03-22
Publicado: 2022-04-25
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