Achados neuropatológicos da Covid-19: uma revisão sistemática
DOI:
https://doi.org/10.34024/rnc.2021.v29.11842Palavras-chave:
Covid-19, Coronavírus, Neuroinflamação, Acidente Vascular CerebralResumo
Introdução. A doença causada pelo Sars-Cov-2, Covid-19, foi identificada pela primeira vez na China e apresentou rápida expansão mundial, sendo reconhecida como pandemia em março de 2020. Apesar de causar uma infecção de vias aéreas, descobertas clínicas recentes e estudos com animais sugerem que o vírus também promove vias neuronais notáveis e comprometimentos do sistema circulatório, levando a lesões no sistema nervoso central. Objetivo. Coletar e analisar os dados publicados entre 2019 e 2020 a respeito de lesões encontradas no sistema nervoso a partir de estudos de necrópsia e de imagem realizados em seres humanos. Método. Uma busca sistemática foi feita nas bases de dados PubMed e Science Direct utilizando os descritores “COVID-19” OU “SARS-CoV-2” OU “Coronavirus” AND “Central Nervous System” OU “Brain” AND “Autopsy” OR “RMI”. Foram incluídos estudos originais primários, publicados entre 2019 e 2020. Foram excluídos estudos realizados em animais, casos não comprovados de contaminação por COVID-19 e estudos in vitro. Resultados. Os principais achados desta revisão sistemática apontam para causas imunológicas, inflamatórias e infecciosas. Hemorragia intracranial e intracerebral e Acidente Vascular Cerebral (AVC) isquêmico foram os principais eventos relatados, sendo que o AVC relacionado a Covid-19 tende a ser mais grave do que outras causas. Conclusão. Embora os dados científicos ainda sejam escassos para explicar as vias de dano do SARS-CoV-2 no sistema nervoso central, as evidências disponíveis sugerem uma correlação entre COVID-19 e complicações neurológicas em alguns pacientes.
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Copyright (c) 2021 Qesya Rodrigues Ferreira, Bruna Teixeira da Costa, Marcelle Machado Mendes, Vinicius Nogueira Cavalcanti, Alberto Christian Luz Santos, David Manoel Pereira Araújo, Patrícia da Silva Oliveira
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Aceito: 2021-09-13
Publicado: 2021-10-06