Hemosiderina, um possível biomarcador para sudep?

Autores

  • Andressa Sampaio Pereira
  • Patrícia de Morais Ferreira Brandão
  • Jerónimo A Auzmend
  • Alberto Lazarowski

DOI:

https://doi.org/10.34024/rnc.2021.v29.12514

Palavras-chave:

Epilepsia, SUDEP, espécies reativas de oxigênio

Resumo

A epilepsia é uma das doenças neurológicas de etiologia complexa que afeta em torno de 50 milhões de pessoas em todo o mundo, e é caracterizada por atividade elétrica anormal e convulsões recorrentes. As convulsões tônico-clônicas generalizadas repetitivas descontroladas (GTCS) são as principais causas de morte súbita inesperada em epilepsia (SUDEP). O estresse hipóxico induzido pela crise epiléptica resulta em disfunções neurocardiogênica, incluindo a sobrecarga de ferro a cardiomiopatia (IOC) que está relacionada à peroxidação lipídica grave causada pela produção de espécies reativas de oxigênio (ROS). A ROS induz a atividade convulsiva recorrente, favorecendo a superexpressão da glicoproteína P (P-gp) no coração. A P-gp desempenha uma função despolarizante em membranas de cardiomiócitos e os canais de potássio (Kir) controlam a excitabilidade celular quanto a repolarização do potencial de ação cardíaco. Todos esses acontecimentos resultam num possível aparecimento de bradicardia severa e arritmia fatal. Diversos estudos têm buscado evidências para diferentes possíveis biomarcadores para potencial previsão do risco de SUDEP evitando seu desfecho fatal.

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Publicado

2021-08-05

Como Citar

Pereira, A. S., Brandão, P. de M. F., Auzmend, J. A., & Lazarowski, A. (2021). Hemosiderina, um possível biomarcador para sudep?. Revista Neurociências, 29. https://doi.org/10.34024/rnc.2021.v29.12514

Edição

Seção

Artigos de Revisão
Recebido em 2021-08-05
Publicado em 2021-08-05